Location: US 45 and Main St, Tupelo Just after the MS 6 split we’ll approach MS 178. Location: US 45 and Front St, Tupelo Exit left ahead for MS 178 west. Stay in the center lane to follow US 45 to I-22. Location: US 45 and McCullough Blvd, Tupelo Exit left for MS 178 west. … Continue reading U.S. Route 45, MS-6 to MS-178